2017 Delaware Membrane Protein Symposium
Membrane proteins are critical for cell-cell recognition, inter- and intracellular signaling, transmembrane transport and cell homeostasis, and are of great interest in understanding human disease and as drug targets. It is estimated that membrane proteins represent >30% of the human genome and are the targets of >50% of all therapeutics on the market today. However, only a small fraction of these important proteins have been isolated, the functions of most of them remain unknown, and membrane proteins make up < 1% of solved high-resolution structures in the Protein Data Bank. Reasons for this lag in membrane protein characterization include difficulties in expressing such proteins in significant quantities, in isolating and purifying them in view of their amphipathic character, and in crystallizing them.
Monday, May 22, 2017 at 8:00am to 5:15pm
Clayton Hall, Room 101-B
John M. Clayton Hall, University of Delaware, Newark, DE 19711, USA