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BME Seminar: Jacqueline Cole

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Dr. Jacqueline Cole, Ph.D.- Assistant Professor

Director, Orthopaedic Mechanobiology Lab
Joint Department of Biomedical Engineering
North Carolina State University & University of North Carolina-Chapel Hill

 

Impaired Bone Adaptation and Osteovascular Function Following Ischemic Stroke

 

Abstract


Functional vasculature is essential for healthy bone remodeling, and vascular dysfunction following ischemic stroke is associated with increased fracture incidence. However, the effects of stroke on microvasculature within bone (osteovasculature) are not well understood. My lab characterizes osteovasculature in mouse models at functional, microstructural, and cellular/molecular levels to study mechanisms contributing to bone fragility. To do this we developed a minimally invasive laser Doppler flowmetry (LDF) technique suitable for monitoring bone perfusion longitudinally during stroke recovery. We also optimized contrast-enhanced microcomputed tomography protocols to measure osteovascular structure and its proximity to bone, which is indicative of its osteogenic potential. Our ongoing work identifying bone-specific biomarkers unique to stroke will inform treatment targets for mitigating the impaired bone adaptation observed post-stroke.

 

Biosketch


Jacque Cole is an Assistant Professor in the Joint Department of Biomedical Engineering at North Carolina State University and the University of North Carolina-Chapel Hill and director of the Orthopaedic Mechanobiology Lab (OML).  She received a Bachelor of Mechanical Engineering from Auburn University and M.S. and Ph.D. degrees in Mechanical Engineering from Cornell University. She completed two postdoctoral fellowships at the University of Michigan in Chemistry and Orthopaedic Surgery. Dr. Cole is committed to K-12 STEM outreach, directing the National Biomechanics Day effort at NC State for the past four years, earning the Best Content Award in 2017 and Greatest Impact Award in 2018 from the American Society of Biomechanics.

Friday, November 8, 2019 at 10:30am to 11:30am

Patrick T. Harker Interdisciplinary Science and Engineering Laboratory, Room 322
221 Academy Street, Newark, DE 19716

Event Type

Students, Academics, Faculty & Staff, Community, College of Engineering, Grad Students & Postdocs, Lectures and Programs

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ISE Lab

Departments

Black American Studies

Website

https://bme.udel.edu/wp-content/uploa...

Group
ENGR - Biomedical Engineering
Contact Email

mperge@udel.edu

Contact Name

Michelle Pergeorelis

Contact Phone

3028314578

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