BME Seminar: Jacqueline Cole
Dr. Jacqueline Cole, Ph.D.- Assistant Professor
Director, Orthopaedic Mechanobiology Lab
Joint Department of Biomedical Engineering
North Carolina State University & University of North Carolina-Chapel Hill
Functional vasculature is essential for healthy bone remodeling, and vascular dysfunction following ischemic stroke is associated with increased fracture incidence. However, the effects of stroke on microvasculature within bone (osteovasculature) are not well understood. My lab characterizes osteovasculature in mouse models at functional, microstructural, and cellular/molecular levels to study mechanisms contributing to bone fragility. To do this we developed a minimally invasive laser Doppler flowmetry (LDF) technique suitable for monitoring bone perfusion longitudinally during stroke recovery. We also optimized contrast-enhanced microcomputed tomography protocols to measure osteovascular structure and its proximity to bone, which is indicative of its osteogenic potential. Our ongoing work identifying bone-specific biomarkers unique to stroke will inform treatment targets for mitigating the impaired bone adaptation observed post-stroke.
Jacque Cole is an Assistant Professor in the Joint Department of Biomedical Engineering at North Carolina State University and the University of North Carolina-Chapel Hill and director of the Orthopaedic Mechanobiology Lab (OML). She received a Bachelor of Mechanical Engineering from Auburn University and M.S. and Ph.D. degrees in Mechanical Engineering from Cornell University. She completed two postdoctoral fellowships at the University of Michigan in Chemistry and Orthopaedic Surgery. Dr. Cole is committed to K-12 STEM outreach, directing the National Biomechanics Day effort at NC State for the past four years, earning the Best Content Award in 2017 and Greatest Impact Award in 2018 from the American Society of Biomechanics.
Friday, November 8, 2019 at 10:30am to 11:30am
Patrick T. Harker Interdisciplinary Science and Engineering Laboratory, Room 322
221 Academy Street, Newark, DE 19716