CBE Seminar: Katy Kao, Texas A&M University
Harnessing the Adaptive Capacity of Biological Systems for Microbial Strain Development
Rational strain development requires a priori knowledge of the genetic determinants involved. However, due to the complexity of biological systems, the genetic determinants for most complex phenotypes are not known, posing a challenge for the rational engineering of biocatalysts. Evolutionary engineering, on the other hand, does not require a prior genetic or mechanistic knowledge of the desired phenotype, and is thus a power tool for strain development. However, traditional evolutionary engineering methods suffer from limitations such as lack of real-time indications of adaptive events, loss of beneficial mutations due to clonal interference as a result of asexual propagation, and the requirement of the desired phenotype to be growth-coupled. Motivated by these limitations, my lab is focused on the development of more effective and efficient evolutionary engineering strategies for both strain development and for the fundamental understandings of evolutionary processes in microbial systems. In this talk, I will present some of our efforts in this area.
Friday, March 31, 2017 at 10:00am to 11:00am
Colburn Lab, Room 102
University of Delaware- Colburn Lab, University of Delaware, 150 Academy St, Newark, DE 19716-3196, USA