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CATEGORIES:Academics,College of Engineering
DESCRIPTION:Exploring Nature's Biomolecular Console Board: Engineered Ligan
 ds for Modernizing the Production of Viral\, Cellular\, and Regenerative Th
 erapies\n\n \n\nHarvest time has come for modern biotechnology and biothera
 peutics\, bringing a cornucopia of products – gene-editing nucleases\, ther
 apeutic viruses and cells\, and engineered tissue constructs – that are def
 ining the medicine of the future. Along with superior therapeutic efficacy\
 , these products feature unprecedented complexity of biomolecular features 
 and range of scales that define their identity\, efficacy\, and safety. Thi
 s complexity poses an arduous - yet exciting - challenge: how to produce an
 d control these complex\, and often labile\, biologics at the volume\, puri
 ty\, and activity that matches the growing demands of clinics and biotech i
 ndustries worldwide? Our approach seeks to leverage affinity triggers to re
 -envision the tools implemented in the construction\, purification\, and ch
 aracterization of biological and biomedical products. Through the last deca
 de\, we integrated structured peptides and peptide-mimetics into materials 
 with controlled morphological\, optical\, and mechanical properties to forg
 e novel multi-modal substrates. In this talk\, I will present some highligh
 ts of our technology portfolio: (1) Photo-affinity and smart adsorbents tha
 t interact with proteins and use light irradiation or biomolecular reconfig
 uration as adsorption controls\, enabling the purification of labile therap
 eutics and gene-editing products\; (2) Sismo-tropic (σεισμός τροπή\, vibrat
 ion-controlled) surfaces that leverage vibration-sensitive peptides and fre
 quency/amplitude-defined perturbation to tailor in real time the dynamic ra
 nge and sensitivity of sensor arrays to a multitude of analytes\, and provi
 de for sensing regeneration to extend their use in evolving systems\; (3) c
 hemo-tropic scaffolds where peptide ligands are used to build multimodal an
 d reconfigurable gradients of surface density and display of growth factors
  that recapitulate the morphogenic patterns of the extracellular matrix.
DTEND:20240315T151500Z
DTSTAMP:20260312T050432Z
DTSTART:20240315T141500Z
GEO:39.680031;-75.749885
LOCATION:Colburn Lab\, 102
SEQUENCE:0
SUMMARY:CBE Seminar: Stefano Menegatti\, NC State University
UID:tag:localist.com\,2008:EventInstance_45640049427155
URL:https://events.udel.edu/event/cbe_seminar_stefano_menegatti_nc_state_un
 iversity
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